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Ua-26408784-1 search menu search options advanced search search help home contact us access old springerlink sign up / log in sign up / log in institutional / athens login english deutsch corporate academic look inside get access find out how to access preview-only content close human genetics january 1997, volume 99, issue 2, pp 202-205 polyclonal origin of medullary carcinoma of the thyroid in multiple endocrine neoplasia type 2 a. generic viagra buy cheap viagra generic viagra online cheapest generic viagra online viagra without a doctor prescription buy generic viagra viagra for sale viagra for sale real viagra for sale buy cheap viagra M. Ferraris, rosa mangerini, gian franco gaetani, cristina romei, aldo pinchera, furio pacini … show all 6 hide look inside get access abstract multiple endocrine neoplasia type 2 (men 2) is a dominantly inherited cancer syndrome characterized by medullary thyroid carcinoma (mtc) and other tumors. Since mtc can also occur in a sporadic form and as familial medullary thyroid carcinoma, this neoplasm offers a unique opportunity to investigate the difference of origin, if any, between the sporadic and the hereditary forms of a tumor. While sporadic malignancies have usually been found to result from a mutational event occurring at the single-cell level and are therefore monoclonal, studies on hereditary neoplasms have been scarce and often produced conflicting results. In order to determine the clonal origin of sporadic mtcs and of those occurring in men 2 syndromes we used a clonality assay based on a polymorphic trinucleotide repeat of the x-linked human androgen-receptor gene. We found that 10 out of 11 mtcs expressed a polyclonal pattern of x inactivation, including a significant percentage of the cases clinically defined as sporadic. Received: 21 may 1996 / revised: 14 august 1996 page %p close plain text look inside other actions export citations register for journal updates about this journal related content supplementary material (0) references (0) about this article title polyclonal origin of medullary carcinoma of the thyroid in multiple endocrine neoplasia type 2 journal human genetics volume 99, issue 2 , pp 202-205 cover date 1997-01-01 doi 10. 1007/s004390050339 print issn 0340-6717 online issn 1432-1203 publisher springer-verlag additional links register for journal updates editorial board about this journal manuscript submission industry sectors biotechnology consumer packaged goods health & hospitals pharma authors a. M. Ferraris (a1) rosa mangerini (a1) gian franco gaetani (a1) cristina romei (a2) aldo pinchera (a2) furio pacini (a2) author affiliations a1. Division of hematological oncology, dipartimento di oncologia clinica e sperimentale, university of genoa and istituto nazionale per la ricerca sul cancro, lazgo rosanna benzi, 10, i-16132 genoa, italy tel. : +39-10-5600933; fax: +39-10-509052, it a2. Istitu.

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